Health Economics›Systemic mastocytosis›All lines of therapy

All lines of therapy

Systemic mastocytosis · 8 regimens

Cost estimates only — modelled on a typical patient (BSA 1.7 m², 70 kg, CrCl 90 mL/min) using the cheapest available formulary presentation. Excludes vial wastage, facility fees, supportive care, and infusion consumables. Not for billing, formulary decisions, or clinical use.

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Cost vs Efficacy · 1 point

Fully pricedPartial pricing

Regimen	Biomarker	Cost/cycle ↓	Cycle	PFS ↕	OS ↕	Est. cycles	Course cost ↕	Evidence
Midostaurin monotherapy Variant #01	—	R 152 836	28d	—	—	~2	~R 305 671 indirect	—
Cladribine monotherapy Variant #03	—	R 34 921	35d	—	—	~1	~R 34 921 indirect	—
Nilotinib monotherapy Variant #01	—	R 28 002	28d	—	—	~2	~R 56 004 indirect	—
Dasatinib monotherapy Variant #01	—	R 12 899	28d	—	—	~2	~R 25 797 indirect	—
Imatinib monotherapy Variant #16	—	R 1 401	28d	~20.0 mo	~53.0 mo	~2	~R 2 801 PFS proxy · indirect	8
Avapritinib monotherapy Variant #01 Partial	—	—	28d	—	—	~2	—	—
Placebo Partial	—	—	—	~4.2 mo	~8.0 mo	—	—	145
Interferon alfa-2b monotherapy Variant #01 Partial	—	—	28d	—	—	~48	—	1

8 of 8 regimens shown