Health Economics›Multiple myeloma›First-line therapy

First-line therapy

Multiple myeloma · 24 regimens

Cost estimates only — modelled on a typical patient (BSA 1.7 m², 70 kg, CrCl 90 mL/min) using the cheapest available formulary presentation. Excludes vial wastage, facility fees, supportive care, and infusion consumables. Not for billing, formulary decisions, or clinical use.

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Cost vs Efficacy · 2 points

Fully pricedPartial pricing

Regimen	Biomarker	Cost/cycle ↓	Cycle	PFS ↕	OS ↕	Est. cycles	Course cost ↕	Evidence
BiRd Variant #01	—	R 31 505	28d	23.0 mo	—	2	R 47 614 PFS proxy	1
Lenalidomide and Dexamethasone (RD) Variant #02	—	R 5 879	28d	—	—	~13	~R 76 427 indirect	—
C-VAMP Variant #01	—	R 5 801	21d	—	—	~2	~R 11 602 indirect	—
VAMP Variant #04	—	R 4 534	21d	—	—	~2	~R 9 067 indirect	—
VAD Variant #02	—	R 2 493	28d	—	—	~5	~R 8 297 indirect	—
VBMCP/VBAD Variant #01 Partial	—	R 2 099	35d	—	—	~2	~R 4 199 indirect	—
DECA Variant #01	—	R 1 863	21d	—	—	~2	~R 3 727 indirect	—
Cyclophosphamide monotherapy Variant #01	—	R 1 680	28d	—	~15.8 mo	~1	~R 1 680 PFS proxy · indirect	1
DEX-IFN Variant #01 Partial	—	R 1 389	42d	—	—	~12	~R 5 555 indirect	—
Dexamethasone monotherapy Variant #03	—	R 1 215	28d	—	—	~4	~R 4 861 indirect	—
VMCP/VCAP Variant #01	—	R 704	21d	—	—	~6	~R 3 028 indirect	—
VMCP/VBAP Variant #01 Partial	—	R 679	21d	—	—	~6	~R 2 577 indirect	—
CVP Variant #01	—	R 613	21d	—	—	~8	~R 4 901 indirect	—
mCOP/MP Variant #01	—	R 581	42d	—	44.0 mo	2	R 1 162 PFS proxy	—
VMCP Variant #01	—	R 560	30d	—	47.6 mo	2	R 1 119 PFS proxy	1
VBMCP Variant #01 Partial	—	R 527	35d	—	—	~2	~R 1 053 indirect	—
ABCM Variant #01 Partial	—	R 498	42d	—	32.0 mo	12	R 5 980 PFS proxy	—
Melphalan and Dexamethasone Variant #05	—	R 433	42d	—	~45.5 mo	~19	~R 8 232 PFS proxy · indirect	2
Melphalan and Prednisone (MP) Variant #18	—	R 132	42d	—	29.1 mo	10	R 1 102 PFS proxy	2
MP (Prednisolone) Variant #01	—	R 119	28d	—	—	~13	~R 1 544 indirect	—
Melphalan monotherapy Variant #01	—	R 73	42d	~50.0 mo	—	~9	~R 660 PFS proxy · indirect	4
VBMC Partial	—	—	—	—	—	—	—	—
M-DEX Partial	—	—	—	—	—	—	—	—
EDAP Partial	—	—	—	—	—	—	—	—

24 of 24 regimens shown