Health Economics›Erdheim-Chester disease›All lines of therapy

All lines of therapy

Erdheim-Chester disease · 3 regimens

Cost estimates only — modelled on a typical patient (BSA 1.7 m², 70 kg, CrCl 90 mL/min) using the cheapest available formulary presentation. Excludes vial wastage, facility fees, supportive care, and infusion consumables. Not for billing, formulary decisions, or clinical use.

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Cost vs Efficacy · 1 point

Fully pricedPartial pricing

Regimen	Biomarker	Cost/cycle ↓	Cycle	PFS ↕	OS ↕	Est. cycles	Course cost ↕	Evidence
Cobimetinib monotherapy Variant #01	—	R 28 004	28d	—	—	~2	~R 56 008 indirect	—
Vemurafenib monotherapy Variant #01	—	R 13 464	28d	~7.2 mo	~15.5 mo	~2	~R 26 928 PFS proxy · indirect	4
Sirolimus and Prednisone Variant #01 Partial	—	R 8 238	30d	—	—	~25	~R 202 752 indirect	—

3 of 3 regimens shown