Health Economics›B-cell acute lymphoblastic leukemia pediatric›Upfront induction therapy

Upfront induction therapy

B-cell acute lymphoblastic leukemia pediatric · 25 regimens

Cost estimates only — modelled on a typical patient (BSA 1.7 m², 70 kg, CrCl 90 mL/min) using the cheapest available formulary presentation. Excludes vial wastage, facility fees, supportive care, and infusion consumables. Not for billing, formulary decisions, or clinical use.

FiltersBiomarker

Y-axis

Cost vs Efficacy

No data points — cost or PFS missing for current selection.

Regimen	Biomarker	Cost/cycle ↓	Cycle	PFS ↕	OS ↕	Est. cycles	Course cost ↕	Evidence
Daunorubicin, Pegaspargase, Vincristine, Prednisone, Dasatinib Variant #01 Partial	BCR::ABL1	R 23 139	28d	—	—	1	R 23 139 PFS proxy	1
Daunorubicin, Pegaspargase, Vincristine, Dexamethasone Variant #01 Partial	—	R 12 738	28d	—	—	~1	~R 12 738 indirect	—
Daunorubicin, Pegaspargase, Vincristine, Prednisone, Imatinib Variant #01 Partial	BCR::ABL1	R 12 190	28d	—	—	1	R 12 190 PFS proxy	1
DOLP (Prednisolone) Variant #01 Partial	—	R 9 349	29d	—	—	~1	~R 9 349 indirect	—
DOLP Variant #16 Partial	—	R 9 311	42d	—	—	~1	~R 9 311 indirect	—
Cytarabine, Daunorubicin, L-Asparaginase, Vincristine, Dexamethasone Variant #01 Partial	—	R 8 407	28d	—	—	~1	~R 8 407 indirect	—
Calaspargase, Daunorubicin, Vincristine, Prednisone Variant #01 Partial	—	R 7 996	35d	—	—	~1	~R 7 996 indirect	—
Pegaspargase, Vincristine, Dexamethasone Variant #01 Partial	—	R 6 494	35d	—	—	~1	~R 6 494 indirect	—
Mercaptopurine and Prednisone Variant #01 Partial	—	R 6 310	35d	—	—	~1	~R 6 310 indirect	—
Cytarabine, Daunorubicin, L-Asparaginase, Teniposide, Vincristine, Prednisone Variant #01 Partial	—	R 5 454	42d	—	—	~1	~R 5 454 indirect	—
Doxorubicin, Methotrexate, Pegaspargase, Vincristine, Methylprednisolone Variant #01 Partial	—	R 4 392	28d	—	—	~1	~R 4 392 indirect	—
Daunorubicin, Vincristine, Prednisolone Variant #01	—	R 3 021	7d	—	—	~2	~R 6 042 indirect	—
Doxorubicin, Mercaptopurine, Pegaspargase, Vincristine, Prednisolone Variant #01 Partial	—	R 2 982	35d	—	—	~1	~R 2 982 indirect	—
Daunorubicin, Pegaspargase, Vincristine, Prednisone Variant #11 Partial	—	R 2 355	42d	—	—	~1	~R 2 355 indirect	—
Mercaptopurine and Methotrexate Variant #05	—	R 2 185	14d	—	—	~26	~R 56 797 indirect	—
Doxorubicin, L-asparaginase, Methotrexate, Vincristine, Prednisone Variant #01 Partial	—	R 2 175	29d	—	—	~1	~R 2 175 indirect	—
COMP Variant #01 Partial	—	R 2 132	37d	—	—	~1	~R 2 132 indirect	—
Doxorubicin, Methotrexate, Vincristine, Prednisone Variant #01	—	R 2 005	28d	—	—	~1	~R 2 005 indirect	—
L-Asparaginase, Vincristine, Prednisolone Variant #02	—	R 1 416	28d	—	—	~1	~R 1 416 indirect	—
Pegaspargase, Vincristine, Prednisone Variant #01 Partial	—	R 1 388	28d	—	—	~1	~R 1 388 indirect	—
L-Asparaginase, Vincristine, Dexamethasone Variant #02 Partial	—	R 934	28d	—	—	~6	~R 5 605 indirect	—
L-Asparaginase, Vincristine, Prednisone Variant #01 Partial	—	R 549	28d	—	—	~1	~R 549 indirect	—
Vincristine and Prednisone Variant #01	—	R 183	5d	—	—	~1	~R 183 indirect	—
Aminopterin monotherapy Partial	—	—	—	—	—	—	—	—
Daunorubicin, Vincristine, Prednisone Partial	—	—	—	—	—	—	—	—

25 of 25 regimens shown